Ziessman H A, Fahey F H, Collen M J
Department of Radiology, Georgetown University Hospital, Washington, D.C. 20007.
Dig Dis Sci. 1992 May;37(5):744-50. doi: 10.1007/BF01296433.
The purpose of this study was to investigate the various phases of gastric emptying using a dual-isotope liquid-solid meal ([99mTc]SC egg sandwich and [111In]DPTA in water) and continuous acquisition in the left anterior oblique view. The study groups consisted of 10 normal controls and 20 diabetics with symptoms suggestive of diabetic gastroparesis. Solid-phase emptying in both groups almost always had a lag phase followed by linear emptying. Liquid-phase emptying was biexponential in 4/10 normals and 12/20 diabetics, with a short early rapid emptying rate (mean T1/2 = 48 min in normals and 79 min in diabetics). Solid emptying was delayed in 10, normal in eight, and rapid in two diabetics. Liquid emptying was delayed in 9/10 diabetics who had delayed solid emptying. Diabetics as a group had a significantly delayed solid lag phase (P less than 0.025), rate of emptying (P less than 0.05) and percent emptying at 90 min (P less than 0.025) compared to normal controls. Diabetic liquid emptying was also significantly delayed (P less than 0.025). The second component of liquid emptying strongly correlated with the solid rate of emptying (r = 0.826 in normals and 0.855 in diabetics). Continuous acquisition of gastric emptying studies in the LAO view has allowed us to better define the various phases of solid and liquid gastric emptying.
本研究的目的是使用双同位素液-固餐（[99mTc]硫胶体鸡蛋三明治和水中的[111In]二乙三胺五醋酸）并在左前斜位连续采集，来研究胃排空的各个阶段。研究组包括10名正常对照者和20名有糖尿病胃轻瘫症状提示的糖尿病患者。两组的固相排空几乎总是先有一个延迟期，随后是线性排空。液相排空在4/10的正常人和12/20的糖尿病患者中呈双指数形式，早期快速排空率短（正常人为48分钟，糖尿病患者为79分钟）。10名糖尿病患者的固体排空延迟，8名正常，2名快速。9/10固体排空延迟的糖尿病患者的液体排空延迟。与正常对照组相比，糖尿病患者作为一个整体，其固体延迟期（P<0.025）、排空率（P<0.05）和90分钟时的排空百分比（P<0.025）均显著延迟。糖尿病患者的液体排空也显著延迟（P<0.025）。液体排空的第二个成分与固体排空率密切相关（正常人为r = 0.826，糖尿病患者为r = 0.855）。在左前斜位连续采集胃排空研究，使我们能够更好地界定胃固体和液体排空的各个阶段。
