Siegel J A, Krevsky B, Maurer A H, Charkes N D, Fisher R S, Malmud L S
Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, Pennsylvania.
Clin Nucl Med. 1989 Jan;14(1):40-6. doi: 10.1097/00003072-198901000-00011.
A standard, dual-isotope meal (Tc-99m-egg sandwich and In-111 DTPA in water) was administered to 14 normal volunteers and 37 patients, who had not undergone gastric surgery, to determine if the emptying characteristics of the liquid phase alone could accurately predict delayed solid emptying. Delayed gastric emptying was defined clinically as a solid half-emptying time more than two standard deviations greater than the mean for normal volunteers. Linear regression analysis was performed on the natural logarithm of liquid fractional retention at each time interval to yield a slope and y-intercept for each subject. There was no significant difference (0.6 less than P less than 0.8) between volunteers and patients with normal solid emptying for the liquid slope. In patients who exhibited delayed gastric emptying for solids, the liquid slopes were significantly different from the normal values (P less than .001). There was a high correlation of liquid slope to solid half-emptying time in all patients and volunteers (r = -0.80, P less than .001). Comparison of the liquid slope measurement to solid half-emptying time criteria revealed a sensitivity of 96%, a specificity of 100%, and a predictive value of 100% for the slope test. These results suggest that delayed gastric emptying can be accurately detected with a liquid-solid meal using only a single-liquid label.
对14名正常志愿者和37名未接受过胃部手术的患者给予标准双同位素餐（99m锝标记的鸡蛋三明治和111铟标记的二乙三胺五乙酸水溶液），以确定仅液相排空特征能否准确预测固体排空延迟。临床上，胃排空延迟定义为固体半排空时间比正常志愿者平均值高出两个标准差以上。对每个时间间隔的液体分数潴留自然对数进行线性回归分析，得出每个受试者的斜率和y轴截距。固体排空正常的志愿者和患者之间的液体斜率无显著差异（0.6＜P＜0.8）。在固体排空延迟的患者中，液体斜率与正常值有显著差异（P＜0.001）。所有患者和志愿者的液体斜率与固体半排空时间高度相关（r = -0.80，P＜0.001）。将液体斜率测量结果与固体半排空时间标准进行比较，发现斜率测试的敏感性为96%，特异性为100%，预测值为100%。这些结果表明，仅使用单一液体标记的液固混合餐就能准确检测胃排空延迟。
