Fisher R S, Malmud L S, Bandini P, Rock E
Clin Nucl Med. 1982 May;7(5):215-21. doi: 10.1097/00003072-198205000-00005.
The purposes of this study were to use a noninvasive scintigraphic technique to measure gastric emptying of liquids and solids simultaneously, to study the interactions between emptying of the liquid and solid components of meals in normal subjects, and to employ dual isotope gastric scintigraphy to evaluate gastric emptying of liquids and solids in patients with clinical evidence of gastric outlet obstruction. The solid component of the test meal consisted of chicken liver, labeled in vivo with Tc-99m sulfur colloid, and the liquid component was water mixed with In-111 DTPA. The rates of emptying were quantitated using a gamma camera on line to a digital computer. Twenty normal subjects were studied using this combined solid-liquid meal. Ten of them also ingested a liquid meal alone and ten a solid meal alone. Liquid emptied from the stomach significantly more rapidly than did solids. The emptying curve for liquids was exponential compared to a linear emptying curve for solids. The gastric emptying rate of the liquid component was slowed significantly by simultaneous ingestion of solids, but the emptying rate of solids was not affected by liquids. Several patients with clinical gastric outlet obstruction were evaluated. Both combined and selective abnormalities for gastric emptying of liquids and solids were demonstrated.
本研究的目的是使用一种非侵入性闪烁扫描技术同时测量液体和固体的胃排空，研究正常受试者进餐时液体和固体成分排空之间的相互作用，并采用双同位素胃闪烁扫描术评估有胃出口梗阻临床证据患者的液体和固体胃排空情况。试验餐的固体成分由用锝-99m硫胶体在体内标记的鸡肝组成，液体成分是与铟-111二乙三胺五乙酸混合的水。使用γ相机在线连接数字计算机对排空速率进行定量。使用这种固体-液体混合餐对20名正常受试者进行了研究。其中10人还单独摄入了液体餐，10人单独摄入了固体餐。液体从胃中排空的速度明显比固体快。与固体的线性排空曲线相比，液体的排空曲线呈指数形式。同时摄入固体显著减慢了液体成分的胃排空速率，但固体的排空速率不受液体影响。对几名有临床胃出口梗阻的患者进行了评估。结果显示了液体和固体胃排空的联合及选择性异常情况。
