Tóth L, Szénási P, Jámbor G, Kammerer L, Romics L
Fövárosi István Kórház II, Belosztály, Budapest, Hungary.
Diabetes Res Clin Pract. 1992 Feb;15(2):143-8. doi: 10.1016/0168-8227(92)90018-m.
Changes of platelet aggregation in relation to macroangiopathy and to some of its risk factors were observed in microangiopathy-free, well-controlled type 1 diabetic males. Platelet aggregate ratio was generally lower in patients (n = 77) than in age-matched healthy subjects (n = 48). In the absence of cigarette smoking, hypertension, obesity and hypercholesterolemia (n = 25) in vitro platelet hyperaggregation was found induced with epinephrine, collagen or arachidonic acid, and to a lesser degree with ADP. There was no change in the presence of at least one risk factor in addition to diabetes (n = 29), but there was a further significant increase in platelet aggregation when overt coronary, cerebral or peripheral artery disease was present (n = 23).
在无微血管病变、病情控制良好的1型糖尿病男性患者中，观察了血小板聚集与大血管病变及其某些危险因素的关系。患者（n = 77）的血小板聚集率总体上低于年龄匹配的健康受试者（n = 48）。在不吸烟、无高血压、肥胖和高胆固醇血症的患者中（n = 25），发现肾上腺素、胶原或花生四烯酸可诱导体外血小板高聚集，而二磷酸腺苷诱导的程度较小。除糖尿病外，至少存在一种危险因素的患者（n = 29）血小板聚集无变化，但存在明显冠状动脉、脑或外周动脉疾病的患者（n = 23）血小板聚集进一步显著增加。
