Esnard A, Esnard F, Guillou F, Gauthier F
Laboratoire d'Enzymologie et Chimie des Protéines, URA CNRS 1334, Université François Rabelais, Tours, France.
FEBS Lett. 1992 Mar 30;300(2):131-5. doi: 10.1016/0014-5793(92)80180-o.
The Sertoli cells of the rat testis produce cystatin C, a cysteine proteinase inhibitor. Primary culture of Sertoli cells secreted both unglycosylated and glycosylated forms of rat cystatin C. Despite the low concentration of cystatin C in rete testis fluid, equilibrium dissociation constants (Ki) for the interaction between cystatin C and lysosomal cathepsins indicate that this molecule could be involved in the local regulation of testicular cysteine proteinase activity which may be necessary for spermatogenesis and spermiogenesis.
大鼠睾丸的支持细胞产生半胱氨酸蛋白酶抑制剂胱抑素C。支持细胞的原代培养分泌了未糖基化和糖基化形式的大鼠胱抑素C。尽管睾丸网液中胱抑素C的浓度较低，但胱抑素C与溶酶体组织蛋白酶之间相互作用的平衡解离常数（Ki）表明，该分子可能参与睾丸半胱氨酸蛋白酶活性的局部调节，而这对于精子发生和精子形成可能是必需的。
