Vähä-Eskeli K, Erkkola R, Irjala K, Uotila P, Poranen A K, Säteri U
Department of Obstetrics and Gynecology, University of Turku, Finland.
Eur J Obstet Gynecol Reprod Biol. 1992 Jan 31;43(2):97-103. doi: 10.1016/0028-2243(92)90065-7.
The effect of heat stress on plasma prostacyclin and thromboxane A2 and serum estradiol, estriol and progesterone responses was studied in pregnant and non-pregnant women. Group I consisted of 15 healthy non-pregnant women, group II of 23 women 13-14 weeks pregnant, and group III of 23 women 36-37 weeks pregnant. Blood samples were taken before the heat stress, at the end of the stress (70 degrees C for 20 min) and 20 min and/or 45 min after the end of stress. The rectal temperature increased 0.3-0.4 degrees C. The concentration of progesterone did not change during the experiment but that of estradiol increased by 11% (P less than 0.005) in group II and by 10% (P less than 0.01) in group III after the end of the stress. Estriol increased only in group III (by 12%, P less than 0.005) after the end of the stress and the increase was higher as compared to group II (P less than 0.005). The metabolite of prostacyclin increased only in group III by 15% (P less than 0.05) during the heat stress. The metabolite of thromboxane A2 decreased in group II by 20% (P less than 0.005) at the end of the stress while there was no change in group III. The fetal heart rate reactivity remained unchanged and only few uterine contractions were recorded. The small changes found in the levels of prostanoids and placental steroids in response to heat stress do not seem to have any deleterious effects on fetal well-being. The slightly increased concentration of placental steroids may rather reflect changes in metabolism than an increase in uteroplacental blood flow.
在孕妇和非孕妇中研究了热应激对血浆前列环素、血栓素A2以及血清雌二醇、雌三醇和孕酮反应的影响。第一组由15名健康非孕妇组成，第二组由23名怀孕13 - 14周的妇女组成，第三组由23名怀孕36 - 37周的妇女组成。在热应激前、应激结束时（70摄氏度，持续20分钟）以及应激结束后20分钟和/或45分钟采集血样。直肠温度升高了0.3 - 0.4摄氏度。实验过程中孕酮浓度未发生变化，但应激结束后，第二组雌二醇浓度升高了11%（P < 0.005），第三组升高了10%（P < 0.01）。应激结束后，仅第三组雌三醇升高（升高12%，P < 0.005），且与第二组相比升高幅度更大（P < 0.005）。在热应激期间，仅第三组前列环素代谢物升高了15%（P < 0.05）。应激结束时，第二组血栓素A2代谢物降低了20%（P < 0.005），而第三组无变化。胎儿心率反应性保持不变，仅记录到少量子宫收缩。热应激后类前列腺素和胎盘类固醇水平的微小变化似乎对胎儿健康没有任何有害影响。胎盘类固醇浓度略有升高可能更多地反映了代谢变化而非子宫胎盘血流量增加。
