Kukkonen-Harjula K, Oja P, Vuori I, Pasanen M, Lange K, Siitonen S, Metsä-Ketelä T, Vapaatalo H
President Urho Kaleva Kekkonen Institute for Health Promotion Research (UKK Institute), Tampere, Finland.
Eur J Appl Physiol Occup Physiol. 1994;69(1):10-5. doi: 10.1007/BF00867920.
Indicators of cardiovascular strain were studied in 12 healthy young men under the influence of drugs affecting the autonomic nervous system during the course of taking a sauna bath. There were four bath sessions: one without a drug (control) and three with drug pretreatment (Atenolol 50 mg or Scopolamine 0.3 mg or their combination taken orally 2 h before the bath). The time spent in the hot room depended on the subjective rating of heat stress. Its mean duration at a temperature of 88 degrees C (dry bulb) was 22 (range 14-33) min and did not differ significantly among the sessions. In the Atenolol experiment the mean resting heart rate before the bath was significantly lower (P < 0.001, ANOVA of repeated measures) than in the other experiments. The increase in heart rate per minute of heat exposure was significantly lower (P < 0.001) in the Atenolol experiment and higher (P = 0.017) in the Scopolamine experiment than in the other experiments. The systolic blood pressure increased more slowly (P = 0.004) and the diastolic pressure decreased less (P = 0.02) in the Atenolol experiment than in the other experiments. Heart rate and blood pressure returned to their initial levels during the 30-min recovery after the heat exposure. The plasma noradrenaline concentrations increased approximately twofold during all of the bath sessions, whereas the plasma adrenaline and serum thromboxane B2 concentrations showed no consistent alterations. A small oral dose of Scopolamine alone or in combination with Atenolol produced no marked cardiovascular strain in healthy men during a sauna bath.
在12名健康年轻男性中，研究了在洗桑拿浴过程中服用影响自主神经系统的药物时心血管应激指标。共有四次洗浴过程：一次不服用药物（对照），三次在洗浴前2小时口服药物预处理（阿替洛尔50毫克或东莨菪碱0.3毫克或两者联合使用）。在热室中停留的时间取决于热应激的主观评分。在88摄氏度（干球温度）下，其平均持续时间为22分钟（范围为14 - 33分钟），各次洗浴之间无显著差异。在阿替洛尔实验中，洗浴前的平均静息心率显著低于其他实验（P < 0.001，重复测量方差分析）。与其他实验相比，阿替洛尔实验中每分钟热暴露引起的心率增加显著更低（P < 0.001），而东莨菪碱实验中则更高（P = 0.017）。与其他实验相比，阿替洛尔实验中收缩压升高更慢（P = 0.004），舒张压下降更少（P = 0.02）。热暴露后30分钟恢复期间，心率和血压恢复到初始水平。在所有洗浴过程中，血浆去甲肾上腺素浓度大约增加了两倍，而血浆肾上腺素和血清血栓素B2浓度没有一致的变化。在健康男性洗桑拿浴期间单独小剂量口服东莨菪碱或与阿替洛尔联合使用不会产生明显的心血管应激。
