雾化组织型纤溶酶原激活剂对一名Fontan术后患者塑料支气管炎的长期治疗
Long-term treatment of plastic bronchitis with aerosolized tissue plasminogen activator in a Fontan patient.
作者信息
Wakeham Martin K, Van Bergen Andrew H, Torero Luis E, Akhter Javeed
机构信息
Pediatric Critical Care, Advocate Hope Children's Hospital, Oak Lawn, IL 60453, USA.
出版信息
Pediatr Crit Care Med. 2005 Jan;6(1):76-8. doi: 10.1097/01.PCC.0000149320.06424.1D.
OBJECTIVE
To report the successful treatment of plastic bronchitis with aerosolized tissue plasminogen activator.
DESIGN
Case report.
PATIENTS
A 4-yr-old boy with congenital heart disease, who developed plastic bronchitis 33 months after a Fontan operation
INTERVENTIONS
Long-term treatment with aerosolized tissue plasminogen activator.
MEASUREMENTS AND MAIN RESULTS
We describe the case of a boy who developed recurrent episodes of life-threatening airway obstruction secondary to plastic bronchitis. Following the failure of multiple therapeutic interventions, his condition improved significantly with aerosolized tissue plasminogen activator. Several attempts to wean him off this treatment resulted in clinical deterioration. He has remained on long-term aerosolized tissue plasminogen activator.
CONCLUSION
Treatment of plastic bronchitis with aerosolized tissue plasminogen activator may benefit patients in whom other therapies have failed.
目的
报告雾化组织型纤溶酶原激活剂成功治疗塑料支气管炎的病例。
设计
病例报告。
患者
一名4岁先天性心脏病男孩，在Fontan手术后33个月患塑料支气管炎。
干预措施
长期雾化组织型纤溶酶原激活剂治疗。
测量指标及主要结果
我们描述了一名男孩的病例，该男孩因塑料支气管炎反复出现危及生命的气道阻塞发作。在多种治疗干预均失败后，雾化组织型纤溶酶原激活剂使他的病情显著改善。多次尝试停用这种治疗均导致临床病情恶化。他一直在长期接受雾化组织型纤溶酶原激活剂治疗。
结论
对于其他治疗方法失败的患者，雾化组织型纤溶酶原激活剂治疗塑料支气管炎可能有益。
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