细菌接合：基因组工程的一种潜在工具。
Bacterial conjugation: a potential tool for genomic engineering.
作者信息
Llosa Matxalen, de la Cruz Fernando
机构信息
Departamento de Biología Molecular, Universidad de Cantabria, C. Herrera Oria s/n, 39011 Santander, Spain.
出版信息
Res Microbiol. 2005 Jan-Feb;156(1):1-6. doi: 10.1016/j.resmic.2004.07.008.
PMID:15636742
Abstract
Bacterial conjugation is a mechanism for horizontal DNA transfer with potential for universal DNA delivery. The conjugal machinery can be separated into three functional modules: the relaxosome, the coupling protein, and a type IV protein secretion system. Module interchangeability among different conjugative systems opens up the possibility of "a la carte" engineering of DNA delivery into virtually any cell type.
摘要
细菌接合是一种水平DNA转移机制，具有通用DNA传递的潜力。接合机制可分为三个功能模块：松弛体、偶联蛋白和IV型蛋白质分泌系统。不同接合系统之间的模块互换性为将DNA“按单点菜式”工程化传递到几乎任何细胞类型中开辟了可能性。
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