凝聚性大肠杆菌菌株分泌一种与大肠杆菌溶血素抗原相关的不耐热毒素。
Enteroaggregative Escherichia coli strains secrete a heat-labile toxin antigenically related to E. coli hemolysin.
作者信息
Baldwin T J, Knutton S, Sellers L, Hernandez H A, Aitken A, Williams P H
机构信息
Department of Genetics, University of Leicester, United Kingdom.
出版信息
Infect Immun. 1992 May;60(5):2092-5. doi: 10.1128/iai.60.5.2092-2095.1992.
Abstract
A protein toxin of approximately 120,000 Da secreted by nonhemolytic enteroaggregative Escherichia coli strains cross-reacted in Western blots (immunoblots) with antibodies raised against the C-terminal region of E. coli hemolysin. Treatment of HEp-2 cells with enteroaggregative E. coli or culture supernatants caused elevation of intracellular calcium and stimulated calcium-dependent protein phosphorylation.
摘要
非溶血性肠聚集性大肠杆菌菌株分泌的一种约120,000道尔顿的蛋白质毒素，在蛋白质免疫印迹法（免疫印迹）中与针对大肠杆菌溶血素C末端区域产生的抗体发生交叉反应。用肠聚集性大肠杆菌或培养上清液处理人喉表皮样癌细胞（HEp-2细胞）会导致细胞内钙升高，并刺激钙依赖性蛋白磷酸化。
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