Min Byung-Sun, Huong Ha-Thi-Thanh, Kim Jung-Hee, Jun Hyun-Ju, Na Min-Kyun, Nam Nguyen-Hai, Lee Hyeong-Kyu, Bae KiHwan, Kang Sam-Sik
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
Planta Med. 2004 Dec;70(12):1166-9. doi: 10.1055/s-2004-835846.
Two new furo-1,2-naphthoquinones, crataequinones A (1) and B (2), were isolated from the fruits of Crataegus pinnatifida. The structures of two new compounds were determined as 11,12-dimethoxy-3,4-furo-1,2-naphthoquinone (1) and 11,12-dimethoxy-5-hydroxy-3,4-furo-1,2-naphthoquinone (2) by spectroscopic analysis. The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 microM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1).
从山楂果实中分离出两种新的呋喃并[1,2]萘醌，即山楂醌A（1）和山楂醌B（2）。通过光谱分析确定这两种新化合物的结构分别为11,12-二甲氧基-3,4-呋喃并[1,2]萘醌（1）和11,12-二甲氧基-5-羟基-3,4-呋喃并[1,2]萘醌（2）。化合物1和2对细胞间黏附分子-1（ICAM-1）的表达显示出显著的抑制活性，IC50值分别为33和90微摩尔。
