Inam Neuroscience Research Center, Wonkwang University Sanbon Medical Center, Sanbon-dong, Gunpocity, Kyunggi-Do 435-040, South Korea.
Bioorg Med Chem Lett. 2010 Feb 1;20(3):991-3. doi: 10.1016/j.bmcl.2009.12.059. Epub 2009 Dec 22.
Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 1 microM, and 3 showed gelatinases A and B inhibitory activity (IC(50)) at 0.4 and 2.3 microM, respectively.
从蔷薇科山楂属植物山楂叶甲醇提取物中分离得到 4 种低聚原花青素。研究胶原酶和明胶酶抑制的天然成分得到 4 种低聚原花青素。其中，2 和 3 在低于 1 μM 的浓度下表现出胶原酶抑制活性（IC50），3 在 0.4 和 2.3 μM 时分别表现出对明胶酶 A 和 B 的抑制活性（IC50）。
