Linn D K, Zimmerman T J, Nardin G F, Yung R, Berberich S, DuBiner H, Fuqua M
Department of Ophthalmology, University of Louisville, Kentucky 40202.
Am J Ophthalmol. 1989 Feb 15;107(2):133-6. doi: 10.1016/0002-9394(89)90211-0.
Thirty-two patients were randomly assigned to a treatment or a control group to determine the dose-response and duration of action of intracameral carbachol on immediate postoperative intraocular pressure after extracapsular cataract extraction using a viscoelastic substance. Patients in the treatment group received 0.5, 0.25, or 0.1 ml of 0.01% intracameral carbachol. Patients in the control group received 0.1 or 0.5 ml of balanced salt solution. Intraocular pressures of all patients were measured preoperatively and at three, six, 12, 24, and 48 hours postoperatively. The control group as a whole showed a 9.5-mm Hg intraocular pressure rise at three hours, a 10.0-mm Hg rise at six hours, a 9.0-mm Hg rise at 12 hours, and a 7.2-mm Hg rise at 24 hours postoperatively. The group treated with 0.5 ml of carbachol maintained stable intraocular pressures through the 48-hour measurement period. The groups treated with 0.25 and 0.1 ml of carbachol maintained stable intraocular pressures through 24 hours postoperatively. The differences in intraocular pressure were statistically significant for all treated groups through the 24-hour measurement.
32名患者被随机分为治疗组或对照组，以确定前房注射卡巴胆碱在使用粘弹性物质行白内障囊外摘除术后对即时眼压的剂量反应及作用持续时间。治疗组患者接受0.01%前房注射卡巴胆碱0.5、0.25或0.1 ml。对照组患者接受0.1或0.5 ml平衡盐溶液。所有患者在术前以及术后3、6、12、24和48小时测量眼压。对照组总体上在术后3小时眼压升高9.5 mmHg，6小时升高10.0 mmHg，12小时升高9.0 mmHg，24小时升高7.2 mmHg。接受0.5 ml卡巴胆碱治疗的组在48小时测量期内眼压保持稳定。接受0.25和0.1 ml卡巴胆碱治疗的组在术后24小时内眼压保持稳定。在24小时测量期内，所有治疗组的眼压差异均具有统计学意义。
