Bohr Johan, Larsson Lars-Göran, Eriksson Sune, Järnerot Gunnar, Tysk Curt
Department of Medicine, Division of Gastroenterology, Orebro University Hospital, Orebro, Sweden.
Eur J Gastroenterol Hepatol. 2005 Jan;17(1):121-4. doi: 10.1097/00042737-200501000-00022.
Collagenous colitis is generally regarded as a benign disease with few serious complications. We report two women with collagenous colitis who presented with colonic perforation, one spontaneously and one 7 days after a barium enema, and a review of the literature. Including the present cases, 13 patients with collagenous colitis and colonic perforation have been reported, in two patients spontaneously and in 11 patients after a colonoscopy or barium enema. All were operated on except one patient who recovered after medical treatment. The pathogenesis of this complication is unknown. We propose that there might be a connection between mucosal tears and colonic perforation in collagenous colitis.
胶原性结肠炎通常被视为一种良性疾病，严重并发症较少。我们报告了两名患有胶原性结肠炎并出现结肠穿孔的女性，其中一名是自发性穿孔，另一名在钡剂灌肠后7天出现穿孔，并对相关文献进行了综述。包括本病例在内，已有13例胶原性结肠炎合并结肠穿孔的患者被报道，其中2例为自发性穿孔，11例在结肠镜检查或钡剂灌肠后发生穿孔。除1例经药物治疗后康复的患者外，其余均接受了手术治疗。这种并发症的发病机制尚不清楚。我们认为胶原性结肠炎中黏膜撕裂与结肠穿孔之间可能存在关联。
