津巴布韦农村女性中单纯疱疹病毒2型流行率呈流行比例：与其他性传播感染的关联

Herpes simplex virus type 2 prevalence of epidemic proportions in rural Zimbabwean women: association with other sexually transmitted infections.

作者信息

Kjetland Eyrun Floerecke, Gwanzura Lovemore, Ndhlovu Patricia D, Mduluza Takafira, Gomo Exnevia, Mason Peter R, Midzi Nicholas, Friis Henrik, Gundersen Svein Gunnar

机构信息

Department of Infectious Diseases, Centre for Imported and Tropical Diseases, Ullevaal University Hospital, 0407 Oslo, Norway.

出版信息

Arch Gynecol Obstet. 2005 Jun;272(1):67-73. doi: 10.1007/s00404-004-0689-8. Epub 2005 Jan 13.

DOI:10.1007/s00404-004-0689-8

PMID:15647913

Abstract

INTRODUCTION

Syndromic management of sexually transmitted infections (STIs) is one important strategy in human immunodeficiency virus (HIV) prevention in developing countries, but there is a scarcity of rural community-based data on the relative prevalences of the STIs. We sought to determine the prevalences of the STIs and their clinical correlates in rural Zimbabwean women.

METHODS

A cross-sectional study was conducted among 527 sexually active, non-pregnant, non-menopausal women between the ages of 20 and 49 years.

RESULTS

The seroprevalence for herpes simplex virus type 2 (HSV-2), HIV, trichomoniasis and syphilis were 64.5, 29.3, 24.7 and 6.2% respectively. HSV-2 seropositivity was significantly associated with current non-syphilitic ulcers (adjusted odds ratio [OR] 4.91, 95% confidence interval [CI] 1.08-22.34, p = 0.040). HSV-2 seroprevalence peaked at the age of 35 whereas HIV peaked at 25. The two diseases were strongly associated (OR 2.92, 95% CI 1.85-4.65, p < 0.001).

CONCLUSION

There is evidence of rural epidemics of both HSV-2 and HIV, and a change in the aetiology of genital ulcers in rural Zimbabwe.

摘要

引言

性传播感染（STIs）的综合征管理是发展中国家预防人类免疫缺陷病毒（HIV）的一项重要策略，但关于这些性传播感染相对患病率的农村社区数据却很匮乏。我们试图确定津巴布韦农村女性中性传播感染的患病率及其临床关联因素。

方法

对527名年龄在20至49岁之间、有性活动、未怀孕、未绝经的女性进行了一项横断面研究。

结果

单纯疱疹病毒2型（HSV-2）、HIV、滴虫病和梅毒的血清阳性率分别为64.5%、29.3%、24.7%和6.2%。HSV-2血清阳性与当前非梅毒溃疡显著相关（调整后的优势比[OR]为4.91，95%置信区间[CI]为1.08 - 22.34，p = 0.040）。HSV-2血清阳性率在35岁时达到峰值，而HIV在25岁时达到峰值。这两种疾病密切相关（OR为2.92，95% CI为1.85 - 4.65，p < 0.001）。