环孢素治疗肺出血肾炎综合征

Ciclosporin in Goodpasture's syndrome.

作者信息

Quérin S, Schürch W, Beaulieu R

机构信息

Department of Medicine, Hôtel-Dieu de Montréal Hospital, Montréal, Québec, Canada.

出版信息

Nephron. 1992;60(3):355-9. doi: 10.1159/000186778.

DOI:10.1159/000186778

PMID:1565189

Abstract

We report the case of a 39-year-old male patient with Goodpasture's syndrome. Despite therapy with prednisone, cyclophosphamide and plasma exchanges, serum creatinine (Scr) progressively increased up to 10.3 mg/dl (936 mumol/l) and hemoptysis recurred 3 months after initiation of treatment. Ciclosporin (CS) starting at 6 mg/kg/day was given. Scr began to decrease 2 weeks later and eventually stabilized at approximately 2.0 mg% (182 mumol/l). This case illustrates one of the potential uses of CS in human glomerular disease.

摘要

我们报告了一例患有古德帕斯彻综合征的39岁男性患者的病例。尽管使用泼尼松、环磷酰胺和血浆置换进行治疗，但血清肌酐（Scr）仍逐渐升高至10.3 mg/dl（936 μmol/l），并且在治疗开始3个月后咯血复发。给予起始剂量为6 mg/kg/天的环孢素（CS）。2周后Scr开始下降，最终稳定在约2.0 mg%（182 μmol/l）。该病例说明了CS在人类肾小球疾病中的一种潜在用途。