阔叶乌檀根皮水提取物对大鼠和小鼠的神经药理学作用
Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice.
作者信息
Amos S, Abbah J, Chindo B, Edmond I, Binda L, Adzu B, Buhari S, Odutola A A, Wambebe C, Gamaniel K
机构信息
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P. M. B. 21, Garki, Abuja, Nigeria.
出版信息
J Ethnopharmacol. 2005 Feb 10;97(1):53-7. doi: 10.1016/j.jep.2004.10.003. Epub 2004 Dec 13.
The present study evaluated the neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rodents. Effects on the spontaneous motor activity (SMA), exploratory behaviour, pentobarbital sleeping time, apomorphine-induced stereotypic behaviour and motor coordination (rota-rod performance) were investigated. The extract (50-200 mg/kg p.o.) significantly (P<0.05) decreased the SMA and exploratory behaviour in mice and prolonged pentobarbital sleeping time in rats dose-dependently. The extract also remarkably attenuated the intensity of apomorphine-induced stereotypy dose-dependently in mice, but had no effect on motor coordination as determined by the performance on rota-rod. These results indicate the presence of psychoactive substances in the aqueous extract of the root bark of Nauclea latifolia.
本研究评估了阔叶乌檀根皮水提取物对啮齿动物的神经药理学作用。研究了其对自发运动活动（SMA）、探索行为、戊巴比妥睡眠时间、阿扑吗啡诱导的刻板行为和运动协调性（转棒试验表现）的影响。提取物（50 - 200 mg/kg口服）显著（P<0.05）降低了小鼠的SMA和探索行为，并剂量依赖性地延长了大鼠的戊巴比妥睡眠时间。该提取物还剂量依赖性地显著减轻了阿扑吗啡诱导的小鼠刻板行为的强度，但对转棒试验所测定的运动协调性没有影响。这些结果表明阔叶乌檀根皮水提取物中存在精神活性物质。
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