高尔基体复合自身抗原的独特和共同特征。

Unique and shared features of Golgi complex autoantigens.

作者信息

Nozawa Kazuhisa, Fritzler Marvin J, Chan Edward K L

机构信息

Department of Oral Biology, University of Florida, Health Science Center, 1600 SW Archer Road, Gainesville, FL 32610-0424, USA.

出版信息

Autoimmun Rev. 2005 Jan;4(1):35-41. doi: 10.1016/j.autrev.2004.06.002.

DOI:10.1016/j.autrev.2004.06.002

PMID:15652777

Abstract

Here we summarize recent advances in the characterization of autoimmune antigens associated with the Golgi complex. All Golgi autoantigens identified to date are high molecular weight proteins rich in coiled-coil domains and localized to the cytoplasmic face of the Golgi cisternae. The characteristic features of these Golgi autoantigens are interestingly similar to selected human autoantigens reported in other intracellular compartments such as endosome, centrosome, and centromere. The implication of this class of autoantigens in autoimmunity is discussed.

摘要

在此，我们总结了与高尔基体复合体相关的自身免疫抗原特征的近期进展。迄今为止鉴定出的所有高尔基体自身抗原都是富含卷曲螺旋结构域的高分子量蛋白质，定位于高尔基池的胞质面。有趣的是，这些高尔基体自身抗原的特征与在其他细胞内区室（如内体、中心体和着丝粒）中报道的特定人类自身抗原相似。本文讨论了这类自身抗原在自身免疫中的意义。