Bando Hajime, Ikuno Yasushi, Choi Jun-Sub, Tano Yasuo, Yamanaka Ichiro, Ishibashi Tatsuro
Department of Ophthalmology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Am J Ophthalmol. 2005 Jan;139(1):197-9. doi: 10.1016/j.ajo.2004.07.027.
To reveal the pathogenesis of myopic foveoschisis (MF).
Clinicopathological report.
Internal limiting membranes (ILMs) were collected from ten patients with MF and five patients with idiopathic macular hole (IMH) as a control. Samples were subjected to transmission electron microscopic study. Characteristics of the ILM were compared between the two groups.
Collagen fiber and cell debris were identified on the inner surface of ILM in seven eyes (70%) with MF, significantly more (P < .05) than found in IMH subjects (0%). More fibrous glial cells were likely to be found on the inner surface of ILM. No significant difference in fibroblast-like cell adhesion was observed.
Collagen fiber and cellular component are suggested to play an important role in developing MF. ILM peeling may be essential for vitrectomy for MF.
揭示近视性黄斑劈裂（MF）的发病机制。
临床病理报告。
收集10例MF患者及5例特发性黄斑裂孔（IMH）患者的内界膜（ILM）作为对照。对样本进行透射电子显微镜研究。比较两组ILM的特征。
7只（70%）MF患眼的ILM内表面发现胶原纤维和细胞碎片，显著多于IMH患者（0%）（P <.05）。ILM内表面更可能发现较多的纤维状神经胶质细胞。在成纤维细胞样细胞黏附方面未观察到显著差异。
胶原纤维和细胞成分在MF的发生发展中可能起重要作用。ILM剥除可能是MF玻璃体切除术的关键。
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