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分歧决策:酵母中细胞分裂的协调

Split decisions: coordinating cytokinesis in yeast.

作者信息

Wolfe Benjamin A, Gould Kathleen L

机构信息

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

出版信息

Trends Cell Biol. 2005 Jan;15(1):10-8. doi: 10.1016/j.tcb.2004.11.006.

Abstract

Cytokinesis in eukaryotes involves the regulated assembly and contraction of a ring comprising filamentous (F)-actin and myosin II. Assembly of the contractile ring occurs through the accumulation of cortical cues at the specified division plane, followed by recruitment of F-actin, myosin II and accessory proteins involved in generating the mature ring. Ring contraction is temporally regulated to occur only after chromosome segregation and, in yeast, it is controlled by a conserved signaling cascade that becomes active only after Cdk1-Cyclin-B inactivation. In this article (which is part of the Cytokinesis series), we discuss recent studies that have begun to clarify both the spatial and the temporal order of ring assembly and that have illuminated the signals that trigger ring contraction in yeast. These studies add to the growing knowledge of the processes that control eukaryotic cell division.

摘要

真核生物中的胞质分裂涉及由丝状(F)-肌动蛋白和肌球蛋白II组成的环的有序组装和收缩。收缩环的组装通过皮质信号在特定分裂平面上的积累而发生,随后募集F-肌动蛋白、肌球蛋白II和参与生成成熟环的辅助蛋白。环收缩在时间上受到调控,仅在染色体分离后发生,在酵母中,它由一个保守的信号级联控制,该信号级联仅在Cdk1-细胞周期蛋白B失活后才激活。在本文(这是胞质分裂系列的一部分)中,我们讨论了最近的研究,这些研究开始阐明环组装的空间和时间顺序,并揭示了触发酵母中环收缩的信号。这些研究增加了我们对控制真核细胞分裂过程的认识。

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