细菌病原体对固有免疫的操控。

Manipulation of innate immunity by bacterial pathogens.

作者信息

Portnoy Daniel A

机构信息

Department of Molecular and Cell Biology, 508 Barker Hall, University of California, Berkeley, Berkeley, CA 94703-3202, USA.

出版信息

Curr Opin Immunol. 2005 Feb;17(1):25-8. doi: 10.1016/j.coi.2004.11.002.

DOI:10.1016/j.coi.2004.11.002

PMID:15653306

Abstract

The past decade has witnessed tremendous growth in two related fields: innate immunity and microbial pathogenesis. Many pathogens have evolved mechanisms to infect their hosts in the face of a fully functional innate immune system, and there are numerous examples by which pathogens avoid recognition and/or suppress inflammation. In this review, I suggest that pathogens not only survive the innate immune response, but use it to promote their pathogenesis.

摘要

在过去十年中，两个相关领域取得了巨大发展：固有免疫和微生物致病机制。面对功能完备的固有免疫系统，许多病原体已进化出感染宿主的机制，而且病原体逃避识别和/或抑制炎症的例子众多。在这篇综述中，我认为病原体不仅能在固有免疫反应中存活，还利用它来促进自身的致病过程。