Uebelhoer Nathan S, Bogle Melissa A, Stewart Brigitte, Arndt Kenneth A, Dover Jeffrey S
Department of Dermatology, Division of Laser Surgery, Naval Medical Center San Diego, CA 92134, USA.
Dermatol Surg. 2007 Apr;33(4):441-8. doi: 10.1111/j.1524-4725.2007.33091.x.
Pulsed 595 nm and 532 nm lasers can effectively diminish or eliminate facial telangiectasia. We performed a split-face, single-blind, controlled, comparison study in an effort to determine their individual and comparative efficacy.
STUDY DESIGN/MATERIALS AND METHODS: Fifteen patients were treated using a 595-nm PDL on one side of the face and a pulsed 532-nm potassium-titanyl-phosphate (KTP) laser on the other. Each subject was evaluated at 3 weeks after three treatments.
Both devices improved telangiectasia. The 532-nm device, however, was at least as effective or more effective than the 595-nm laser in all subjects. On average, the KTP laser achieved 62% clearing after the first treatment and 85% clearing 3 weeks after the third treatment, compared to 49% and 75% for the PDL, respectively. Seventy-nine percent of KTP laser-treated patients continued to have swelling for greater than 1 day versus 71% of PDL-treated patients. Of those patients who noted persistent erythema for at least 1 day after treatment, 58% noted more erythema on the KTP laser-treated side compared to 8% on the PDL-treated side.
Both the 595-nm and the 532-nm pulsed lasers are highly effective in the treatment of facial telangiectasia and redness. The 532-nm KTP laser appears to be more effective but causes more swelling and erythema.
脉冲595纳米和532纳米激光能够有效减轻或消除面部毛细血管扩张。我们开展了一项半脸、单盲、对照比较研究,以确定它们各自的疗效及相互比较的效果。
研究设计/材料与方法:15名患者一侧面部使用595纳米脉冲染料激光(PDL)治疗,另一侧面部使用脉冲532纳米磷酸钛氧钾(KTP)激光治疗。每位受试者在接受三次治疗后3周进行评估。
两种设备均改善了毛细血管扩张情况。然而,在所有受试者中,532纳米设备至少与595纳米激光效果相当,甚至更有效。平均而言,KTP激光首次治疗后实现了62%的清除率,第三次治疗后3周的清除率为85%,相比之下,PDL分别为49%和75%。接受KTP激光治疗的患者中有79%肿胀持续超过1天,而接受PDL治疗的患者中这一比例为71%。在那些治疗后至少1天出现持续性红斑的患者中,58%的患者在KTP激光治疗侧出现了更多红斑,而在PDL治疗侧这一比例为8%。
595纳米和532纳米脉冲激光在治疗面部毛细血管扩张和泛红方面均非常有效。532纳米KTP激光似乎更有效,但会引起更多肿胀和红斑。