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脉冲532纳米KTP激光与595纳米脉冲染料激光治疗面部毛细血管扩张症和弥漫性毛细血管扩张性面部红斑的半脸对照研究

A split-face comparison study of pulsed 532-nm KTP laser and 595-nm pulsed dye laser in the treatment of facial telangiectasias and diffuse telangiectatic facial erythema.

作者信息

Uebelhoer Nathan S, Bogle Melissa A, Stewart Brigitte, Arndt Kenneth A, Dover Jeffrey S

机构信息

Department of Dermatology, Division of Laser Surgery, Naval Medical Center San Diego, CA 92134, USA.

出版信息

Dermatol Surg. 2007 Apr;33(4):441-8. doi: 10.1111/j.1524-4725.2007.33091.x.

Abstract

BACKGROUND AND OBJECTIVES

Pulsed 595 nm and 532 nm lasers can effectively diminish or eliminate facial telangiectasia. We performed a split-face, single-blind, controlled, comparison study in an effort to determine their individual and comparative efficacy.

STUDY DESIGN/MATERIALS AND METHODS: Fifteen patients were treated using a 595-nm PDL on one side of the face and a pulsed 532-nm potassium-titanyl-phosphate (KTP) laser on the other. Each subject was evaluated at 3 weeks after three treatments.

RESULTS

Both devices improved telangiectasia. The 532-nm device, however, was at least as effective or more effective than the 595-nm laser in all subjects. On average, the KTP laser achieved 62% clearing after the first treatment and 85% clearing 3 weeks after the third treatment, compared to 49% and 75% for the PDL, respectively. Seventy-nine percent of KTP laser-treated patients continued to have swelling for greater than 1 day versus 71% of PDL-treated patients. Of those patients who noted persistent erythema for at least 1 day after treatment, 58% noted more erythema on the KTP laser-treated side compared to 8% on the PDL-treated side.

CONCLUSIONS

Both the 595-nm and the 532-nm pulsed lasers are highly effective in the treatment of facial telangiectasia and redness. The 532-nm KTP laser appears to be more effective but causes more swelling and erythema.

摘要

背景与目的

脉冲595纳米和532纳米激光能够有效减轻或消除面部毛细血管扩张。我们开展了一项半脸、单盲、对照比较研究,以确定它们各自的疗效及相互比较的效果。

研究设计/材料与方法:15名患者一侧面部使用595纳米脉冲染料激光(PDL)治疗,另一侧面部使用脉冲532纳米磷酸钛氧钾(KTP)激光治疗。每位受试者在接受三次治疗后3周进行评估。

结果

两种设备均改善了毛细血管扩张情况。然而,在所有受试者中,532纳米设备至少与595纳米激光效果相当,甚至更有效。平均而言,KTP激光首次治疗后实现了62%的清除率,第三次治疗后3周的清除率为85%,相比之下,PDL分别为49%和75%。接受KTP激光治疗的患者中有79%肿胀持续超过1天,而接受PDL治疗的患者中这一比例为71%。在那些治疗后至少1天出现持续性红斑的患者中,58%的患者在KTP激光治疗侧出现了更多红斑,而在PDL治疗侧这一比例为8%。

结论

595纳米和532纳米脉冲激光在治疗面部毛细血管扩张和泛红方面均非常有效。532纳米KTP激光似乎更有效,但会引起更多肿胀和红斑。

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