银屑病中针对蛋白酶抑制剂钙蛋白酶抑制蛋白的自身抗体。
Autoantibodies directed against the protease inhibitor calpastatin in psoriasis.
作者信息
Matsushita Y, Shimada Y, Kawara S, Takehara K, Sato S
机构信息
Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
出版信息
Clin Exp Immunol. 2005 Feb;139(2):355-62. doi: 10.1111/j.1365-2249.2005.02701.x.
Psoriasis is believed to be a T cell-mediated autoimmune disease, but also exhibits autoantibody production. Calpastatin is an endogenous inhibitor of calpain, a ubiquitous protease that regulates inflammatory processes. Anti-calpastatin autoantibody was first identified as an autoantibody specific to rheumatoid arthritis, but has been also detected in other autoimmune diseases. In this study, we examined the presence and levels of anti-calpastatin antibody in 77 psoriasis patients by enzyme-linked immunosorbent assay. Compared with normal controls, psoriasis patients exhibited significantly elevated IgG anti-calpastatin antibody levels that were similar to those found in rheumatoid arthritis patients. Remarkably, IgG anti-calpastatin autoantibody in sera from psoriasis patients inhibited calpastatin activity. Calpain II expression was up-regulated in psoriasis skin lesions compared with normal skin while calpastatin expression was normal. The results of this study reveal the presence of anti-calpastatin autoantibody in psoriasis.
银屑病被认为是一种由T细胞介导的自身免疫性疾病，但也会出现自身抗体产生。钙蛋白酶抑制蛋白是钙蛋白酶的内源性抑制剂，钙蛋白酶是一种调节炎症过程的普遍存在的蛋白酶。抗钙蛋白酶抑制蛋白自身抗体最初被鉴定为类风湿性关节炎特有的自身抗体，但在其他自身免疫性疾病中也有检测到。在本研究中，我们通过酶联免疫吸附测定法检测了77例银屑病患者体内抗钙蛋白酶抑制蛋白抗体的存在情况和水平。与正常对照组相比，银屑病患者的IgG抗钙蛋白酶抑制蛋白抗体水平显著升高，与类风湿性关节炎患者的水平相似。值得注意的是，银屑病患者血清中的IgG抗钙蛋白酶抑制蛋白自身抗体抑制了钙蛋白酶抑制蛋白的活性。与正常皮肤相比，银屑病皮肤病变中钙蛋白酶II的表达上调，而钙蛋白酶抑制蛋白的表达正常。本研究结果揭示了银屑病中存在抗钙蛋白酶抑制蛋白自身抗体。
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