Division of Immunopathology, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
J Clin Lab Anal. 2010;24(1):44-8. doi: 10.1002/jcla.20365.
Psoriasis is a common chronic inflammatory disease of the skin and joints. Autoantibodies have been reported in psoriasis patients. Objective of the study was to see the prevalence of various autoantibodies in patients of psoriasis and its correlation with gender, age, and type. Anti-nuclear antibody and antibody to double-stranded deoxyribonucleic acid were studied by indirect enzyme linked immunosorbent assay, rheumatoid factor was done by latex agglutination, whereas anti-thyroid microsomal antibody (anti-TMA) was by gelatin agglutination method. About 28.8% of psoriasis cases were positive for atl east one autoantibody. Age of onset (P=0.033) and types of psoriasis (P=0.037) had significant association with gender. Anti-double-stranded deoxyribonucleic acid (P=0.029) and anti-thyroid microsomal antibody (P=0.002) had significant association with types of psoriasis. Gender wise distribution of psoriasis in age group had significant (P=0.03) association with anti-TMA. This study concludes that the autoantibodies are found to be present in psoriasis patients or latent autoimmune diseases develop in psoriasis patients without any clinical symptoms.
银屑病是一种常见的皮肤和关节慢性炎症性疾病。已有报道称银屑病患者存在自身抗体。本研究的目的是观察银屑病患者各种自身抗体的患病率及其与性别、年龄和类型的相关性。采用间接酶联免疫吸附试验检测抗核抗体和抗双链脱氧核糖核酸抗体，乳胶凝集法检测类风湿因子，而抗甲状腺微粒体抗体（抗 TMA）则采用凝胶凝集法。大约 28.8%的银屑病病例至少有一种自身抗体呈阳性。发病年龄（P=0.033）和银屑病类型（P=0.037）与性别有显著关联。抗双链脱氧核糖核酸（P=0.029）和抗甲状腺微粒体抗体（P=0.002）与银屑病类型有显著关联。按年龄分组的银屑病在性别分布上与抗 TMA 有显著关联（P=0.03）。本研究得出结论，自身抗体存在于银屑病患者中，或者在没有任何临床症状的情况下，潜伏的自身免疫性疾病在银屑病患者中发展。
