Cossu Antonio, Deiana Angelo, Lissia Amelia, Satta Andrea, Cossu Maria, Dedola Maria Filomena, Bella Michele A, Palmieri Giuseppe, Tanda Francesco
Azienda USL n 1 Sassari, Istituto di Anatomia ed Istologia Patologica, Sassari, Italy.
Tumori. 2004 Sep-Oct;90(5):510-3. doi: 10.1177/030089160409000514.
A case of angiotropic lymphoma involving renal glomeruli and interstitial vessels associated with nephrotic syndrome and with minor lesions in the glomerular basal membrane is reported. A 56-year-old woman had fever, weakness and clinical findings of a nephrotic syndrome with normal renal function. Renal biopsy revealed that the glomeruli were infiltrated by neoplastic lymphoid cells positive for CD20 and CD45; the glomerular basement membranes showed a pattern of minimal change disease. This case and our review of the literature suggest that the rare association of intravascular lymphoma and glomerular disease is more than coincidental.
报告了一例血管嗜性淋巴瘤累及肾小球和间质血管，伴有肾病综合征且肾小球基底膜有轻微病变的病例。一名56岁女性出现发热、虚弱以及肾功能正常的肾病综合征临床表现。肾活检显示肾小球被CD20和CD45阳性的肿瘤性淋巴细胞浸润；肾小球基底膜呈现微小病变疾病的模式。该病例及我们对文献的回顾表明，血管内淋巴瘤与肾小球疾病的罕见关联并非偶然。
