McCormick S D, Hasegawa S, Hirano T
Ocean Research Institute, University of Tokyo, Japan.
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3635-8. doi: 10.1073/pnas.89.8.3635.
The skin, particularly the opercular membrane of some teleosts, contains mitochondrion-rich "chloride" cells and has been widely used as a model to study branchial salt-extrusion mechanisms in seawater fish. Skin isolated from the operculum of the freshwater Nile tilapia (Oreochromis niloticus) can transport Ca2+ against an ionic and electrical gradient. Adaptation of Nile tilapia to a low-Ca2+ environment increased the capacity of the opercular membrane to transport Ca2+. The density of mitochondrion-rich cells increased in parallel with Ca2+ transport capacity. The results demonstrate net Ca2+ uptake by vertebrate skin and strongly implicate mitochondrion-rich cells as the site of Ca2+ uptake in fresh water.
皮肤，尤其是一些硬骨鱼的鳃盖膜，含有富含线粒体的“氯化物”细胞，并且已被广泛用作研究海水鱼鳃部排盐机制的模型。从淡水尼罗罗非鱼（Oreochromis niloticus）鳃盖分离出的皮肤能够逆离子和电势梯度转运Ca2+。尼罗罗非鱼适应低Ca2+环境会增加鳃盖膜转运Ca2+的能力。富含线粒体的细胞密度与Ca2+转运能力平行增加。这些结果证明了脊椎动物皮肤对Ca2+的净摄取，并有力地表明富含线粒体的细胞是淡水中Ca2+摄取的部位。
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