Stocker H, Ossent P, Heckmann R, Oertle C
Klinik für Geburtshilfe, Jungtier- und Euterkrankheiten mit Ambulatorium, Zürich.
Schweiz Arch Tierheilkd. 1992;134(2):97-104.
Clinical, neurophysiological and histopathological findings of sixteen cases of spinal muscular atrophy in calves are described. The first clinical signs usually were noticed at 2-6 weeks of age. The animals showed weakness in the hindquarters, trembling and ultimate recumbency. There was a marked muscular atrophy in all four extremities. In addition, secondary bronchopneumonia was evident in 11 cases. Histopathological lesions consisted of degenerative changes in the neurons of the ventral horns and the axons of the spinal cord as well as degeneration of nerve axons in the extremities. Neurophysiological measurements revealed spontaneous activity in the muscles of the limbs. The conditions is autosomal recessive. So far 11 bulls have been identified and excluded from breeding.
描述了16头犊牛脊髓性肌萎缩症病例的临床、神经生理学和组织病理学发现。最初的临床症状通常在2至6周龄时被注意到。动物表现出后躯无力、颤抖并最终卧地不起。所有四肢均有明显的肌肉萎缩。此外，11例出现继发性支气管肺炎。组织病理学病变包括脊髓腹角神经元和轴突的退行性变化以及四肢神经轴突的变性。神经生理学测量显示四肢肌肉有自发活动。该病为常染色体隐性遗传。到目前为止，已鉴定出11头公牛并将其排除在繁殖之外。
