Chen Guifei, Su Yan, Chen Siyu, Lin Tiandong, Lin Xueying
The Second Affiliated Hospital of Hainan Medical University Haikou China.
College of Traditional Chinese Medicine Hainan Medical University Haikou China.
Food Sci Nutr. 2025 Aug 28;13(9):e70496. doi: 10.1002/fsn3.70496. eCollection 2025 Sep.
Alzheimer's disease (AD), a progressive neurodegenerative disorder, characterized by amyloid-beta (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation resulted the cognitive memory loss. Despite extensive research, effective therapeutic treatment remains elusive. Polyphenols, naturally occurring bioactive compounds, have emerged as promising neuroprotective agents due to their potent antioxidant, anti-inflammatory, and amyloid-modulating properties. Research indicated that these bioactive compounds have potent antioxidant and anti-inflammatory properties, have garnered significant attention for their potential role in combating AD by targeting its key pathological mechanisms. Preclinical studies highlight the efficacy of various polyphenols, such as resveratrol, curcumin, and epigallocatechin gallate, in improving cognitive function and reducing neurodegeneration. Moreover, in silico approaches, displayed polyphenols mechanistic interactions with key AD targets to reduce pathogenesis. These computational models accelerate drug discovery by predicting binding affinities, optimizing structural modifications, and identifying novel polyphenol derivatives with enhanced therapeutic potential. This review explores the multifaceted role of polyphenols in AD mitigation, emphasizing their impact on oxidative stress and neuroinflammation while integrating in silico evidence to reinforce their therapeutic relevance. Convincingly, through the suppression of key mediators of AD, including oxidative stress, neuroinflammation, amyloid-beta and tau proteins, polyphenols exhibited outstanding therapeutic potential to treat AD.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，其特征为β淀粉样蛋白（Aβ）聚集、tau蛋白过度磷酸化、氧化应激和神经炎症，这些导致了认知记忆丧失。尽管进行了广泛研究，但有效的治疗方法仍然难以捉摸。多酚是天然存在的生物活性化合物，由于其强大的抗氧化、抗炎和淀粉样蛋白调节特性，已成为有前景的神经保护剂。研究表明，这些生物活性化合物具有强大的抗氧化和抗炎特性，因其通过靶向AD的关键病理机制在对抗AD中的潜在作用而备受关注。临床前研究突出了各种多酚，如白藜芦醇、姜黄素和表没食子儿茶素没食子酸酯，在改善认知功能和减少神经退行性变方面的功效。此外，计算机模拟方法展示了多酚与AD关键靶点的机制相互作用以减轻发病机制。这些计算模型通过预测结合亲和力、优化结构修饰以及识别具有增强治疗潜力的新型多酚衍生物来加速药物发现。本综述探讨了多酚在缓解AD中的多方面作用，强调它们对氧化应激和神经炎症的影响，同时整合计算机模拟证据以加强其治疗相关性。令人信服的是，通过抑制AD的关键介质，包括氧化应激、神经炎症、β淀粉样蛋白和tau蛋白，多酚展现出治疗AD的卓越治疗潜力。
