Kato Haruaki, Kobayashi Shinya, Islam Amh Manjurul, Nishizawa Osamu
Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
Int J Urol. 2005 Jan;12(1):117-9. doi: 10.1111/j.1442-2042.2004.00991.x.
Female urethral cancer with a diverticular form is assumed to originate from the para-urethral duct, which is embryologically homologous to the male prostate gland. The purpose of the present paper was to investigate the female para-urethral adenocarcinomas histologically and immunohistochemically.
Surgical specimens obtained from six female patients with para-urethral adenocarcinomas were examined histologically, and an immunohistochemical study using antibodies against carcinoembryonic antigen (CEA), prostate specific antigen (PSA), and chromogranin A was performed.
On histologic examination, the female para-urethral cancers were divided into five cases of mucin-producing-type adenocarcinoma and one case of clear cell-type adenocarcinoma. All five mucin-producing-type adenocarcinomas were positive with anti-CEA, and two of them showed neuroendicrine differentiation. One of them showed a focally positive area with anti-PSA. The clear cell-type adenocarcinoma had no positive reactions to these antibodies.
On the basis of histologic structure, positive CEA staining, and the presence of focal neuroendocrine differentiation, mucin-producing-type adenocarcinomas may arise from the proximal part of the para-urethral duct.
憩室型女性尿道癌被认为起源于尿道旁管，该管在胚胎学上与男性前列腺同源。本文旨在对女性尿道旁腺癌进行组织学和免疫组织化学研究。
对6例女性尿道旁腺癌患者的手术标本进行组织学检查，并使用抗癌胚抗原（CEA）、前列腺特异性抗原（PSA）和嗜铬粒蛋白A的抗体进行免疫组织化学研究。
组织学检查显示，女性尿道旁癌分为5例黏液分泌型腺癌和1例透明细胞型腺癌。所有5例黏液分泌型腺癌抗CEA均呈阳性，其中2例显示神经内分泌分化。其中1例抗PSA呈局灶阳性区。透明细胞型腺癌对这些抗体无阳性反应。
基于组织结构、CEA染色阳性以及局灶性神经内分泌分化的存在，黏液分泌型腺癌可能起源于尿道旁管近端。
