Rane Sharada Raju, Ghodke Ashwini Nivrutti, Vishwasrao Sharvari
Associate Professor, Department of Pathology, BJGMC, Pune, Maharashtra, India.
Assistant Professor, Department of Pathology, BJGMC, Pune, Maharashtra, India.
J Clin Diagn Res. 2017 Jul;11(7):ED01-ED02. doi: 10.7860/JCDR/2017/25261.10127. Epub 2017 Jul 1.
Primary malignancies of female urethra are infrequent, constituting a fraction of less than 1% of genitourinary malignancies. Primary clear-cell adenocarcinoma of the urethra, is even rarer, that histomorphologically resembles clear-cell carcinoma of the female genital tract, occurs predominantly in women and is associated with a relatively poor prognosis. The histogenesis of this rare urethral neoplasm has not been completely determined. Various hypotheses concerning the origin have been postulated, including (1) diverticular origin (2) mullerian origin (3), glandular differentiation of urothelium or urothelial carcinoma. Here, we report a case of 67-year-old female with obstructive urinary symptoms and pain in abdomen, diagnosed with adenocarcinoma of urethra. Immunohistochemistry (IHC) workup of the tumour was done to find the origin of the tumour.
女性尿道原发性恶性肿瘤并不常见，占泌尿生殖系统恶性肿瘤的比例不到1%。尿道原发性透明细胞腺癌更为罕见，其组织形态学类似于女性生殖道透明细胞癌，主要发生于女性，且预后相对较差。这种罕见的尿道肿瘤的组织发生尚未完全明确。关于其起源已提出各种假说，包括（1）憩室起源；（2）苗勒氏管起源；（3）尿路上皮或尿路上皮癌的腺性分化。在此，我们报告一例67岁女性，有排尿梗阻症状和腹痛，诊断为尿道腺癌。对肿瘤进行了免疫组织化学（IHC）检查以确定肿瘤的起源。
