Keyriläinen Jani, Fernández Manuel, Fiedler Stefan, Bravin Alberto, Karjalainen-Lindsberg Marja-Liisa, Virkkunen Pekka, Elo Eva-Maria, Tenhunen Mikko, Suortti Pekka, Thomlinson William
Department of Physical Sciences, University of Helsinki, Gustaf Hällströmin katu 2, FIN-00014 Helsinki, Finland.
Eur J Radiol. 2005 Feb;53(2):226-37. doi: 10.1016/j.ejrad.2004.03.015.
Six excised human breast tissue specimens carrying benign and malignant tumours were examined with the diffraction-enhanced imaging technique. Diffraction-enhanced images were compared with diagnostic screen-film mammograms and the correlation with histological information of the specimens was established. The enhanced visibility of calcifications, some of which were smaller than 0.15 mm in diameter, is reported in detail. Fine details of the structures such as strands of collagen and contours between glandular and adipose tissue, which are barely visible at the contrast detection limit in the conventional absorption-based mammograms, are clearly visible in the diffraction-enhanced images. Microscopic study of the stained histopathological sections unequivocally confirms the correlation of the radiographic findings with the morphologic changes in specimens. An increased soft tissue contrast and a combination of information obtained with disparate diffraction-enhanced images provide better visibility of mammographically indistinguishable features. This kind of additional structural information of the breast tissue is required to improve assessment accuracy and earlier detection of the breast lesions. These advances in image quality make the method a very promising candidate for mammography.
使用衍射增强成像技术对六个切除的携带良性和恶性肿瘤的人类乳腺组织标本进行了检查。将衍射增强图像与诊断性乳腺钼靶平片进行比较，并建立了与标本组织学信息的相关性。详细报道了钙化的增强可见性，其中一些钙化直径小于0.15毫米。在传统基于吸收的乳腺钼靶平片中，在对比度检测极限下几乎不可见的结构细节，如胶原纤维束以及腺组织和脂肪组织之间的轮廓，在衍射增强图像中清晰可见。对染色的组织病理学切片进行显微镜研究明确证实了影像学表现与标本形态学变化之间的相关性。软组织对比度的增加以及从不同的衍射增强图像获得的信息组合，使得乳腺钼靶难以区分的特征具有更好的可见性。为了提高乳腺病变评估的准确性和早期检测，需要这种乳腺组织的额外结构信息。图像质量的这些进步使该方法成为乳腺钼靶检查非常有前景的候选方法。
