在喂食高胆固醇饮食的动物的离体灌注大鼠心脏中，膳食红棕榈油可改善再灌注心脏功能。
Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet.
作者信息
Esterhuyse A J, du Toit E F, Benadè A J S, van Rooyen J
机构信息
Faculty of Applied Sciences, Cape Technikon, Cape Town, South Africa.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2005 Mar;72(3):153-61. doi: 10.1016/j.plefa.2004.10.014.
It has been shown that dietary red palm oil (RPO) supplementation improved reperfusion function. However, no exact protective cellular mechanisms have been established. Our aim was to search for a possible cellular mechanism and a role for fatty acids. Rats were fed a standard rat chow, plus cholesterol and/or RPO-supplementation for 6 weeks. Functional recovery, myocardial phospholipid and cAMP/cGMP levels were determined in isolated rat hearts subjected to 25 min of normothermic total global ischaemia. Dietary RPO in the presence of cholesterol improved aortic output (AO) recovery (63.2+/-3.06%, P<0.05) vs. cholesterol only (36.5+/-6.2%). The improved functional recovery in hearts supplemented with RPO vs. control was preceded by an elevation in the cGMP levels early in ischaemia (RPO 132.9+/-36.3% vs. control 42.7+/-24.4%, P<0.05). Concurrently, cAMP levels decreased (RPO -8.3+/-6.9% vs. control 19.9+/-7.7%, P<0.05). Our data suggest that dietary RPO-supplementation improved reperfusion AO through mechanisms that may include activation of the NO-cGMP and inhibition of the cAMP pathway.
研究表明，膳食补充红棕榈油（RPO）可改善再灌注功能。然而，尚未确定确切的细胞保护机制。我们的目的是寻找可能的细胞机制以及脂肪酸的作用。将大鼠喂食标准大鼠饲料，并添加胆固醇和/或补充RPO，持续6周。在经历25分钟常温全心缺血的离体大鼠心脏中，测定功能恢复、心肌磷脂以及cAMP/cGMP水平。与仅喂食胆固醇的大鼠相比，在存在胆固醇的情况下，膳食补充RPO可改善主动脉输出（AO）恢复（63.2±3.06%，P<0.05），仅喂食胆固醇组为（36.5±6.2%）。与对照组相比，补充RPO的心脏功能恢复改善之前，缺血早期cGMP水平升高（RPO组为132.9±36.3%，对照组为42.7±24.4%，P<0.05）。同时，cAMP水平降低（RPO组为-8.3±6.9%，对照组为19.9±7.7%，P<0.05）。我们的数据表明，膳食补充RPO通过可能包括激活NO-cGMP和抑制cAMP途径的机制改善再灌注AO。
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