Dumont F, Yzet T, Vibert E, Poirier J, Bartoli E, Delcenserie R, Manaouil D, Dupas J L, Bounicaud D, Regimbeau J M
Fédération médicochirurgicale d'hépatogastroentérologie, CHU d'Amiens Nord, 80054 Amiens, France.
Ann Chir. 2005 Jan;130(1):5-14. doi: 10.1016/j.anchir.2004.11.010.
Pancreas divisum, the most frequent congenital malformation of the pancreas, results from the absence of embryologic fusion of the dorsal and ventral pancreatic ducts which keep an autonomy of drainage. The dorsal pancreatic duct is dominant and drains the major part of the pancreatic fluid through a non adapted accessory papilla. The high prevalence of pancreas divisum in patients presenting recurrent acute pancreatitis, the presence of obstructive pancreatitis electively located on the dorsal pancreatic duct and the results of the treatments targeted on the accessory papilla are the arguments pleading for the pathogenic character of the pancreas divisum. Currently, the diagnosis of pancreas divisum is based on magnetic resonance imaging. For symptomatic patients (after exclusion of patients with intestinal functional disorders), results of endoscopic sphincterotomy or surgical sphincteroplasty are favourable in 75% of patients with recurrent acute pancreatitis. They are worse in patients with chronic pain. Surgical sphincteroplasty must be discussed in the same manner as the endoscopic treatment for sometimes avoiding multiplication of the procedures.
胰腺分裂是胰腺最常见的先天性畸形,它是由于背侧和腹侧胰管胚胎融合缺失所致,二者保持引流自主性。背侧胰管占主导地位,通过一个不匹配的副乳头引流大部分胰液。胰腺分裂在复发性急性胰腺炎患者中的高发病率、选择性位于背侧胰管的梗阻性胰腺炎的存在以及针对副乳头的治疗结果,都支持胰腺分裂具有致病特性这一观点。目前,胰腺分裂的诊断基于磁共振成像。对于有症状的患者(排除肠道功能障碍患者后),内镜下括约肌切开术或手术括约肌成形术对75%的复发性急性胰腺炎患者效果良好。对慢性疼痛患者效果较差。手术括约肌成形术的讨论方式应与内镜治疗相同,因为有时要避免手术次数过多。