Brakenhielm Ebba, Richard Vincent
Normandy University, UniRouen, Inserm (Institut National de la Santé et de la Recherche Médicale) UMR1096 (EnVI Laboratory), FHU REMOD-VHF, Rouen, France.
Vasc Biol. 2019 Mar 28;1(1):H9-H15. doi: 10.1530/VB-19-0006. eCollection 2019.
Despite tremendous efforts in preclinical research over the last decades, the clinical translation of therapeutic angiogenesis to grow stable and functional blood vessels in patients with ischemic diseases continues to prove challenging. In this mini review, we briefly present the current main approaches applied to improve pro-angiogenic therapies. Specific examples from research on therapeutic cardiac angiogenesis and arteriogenesis will be discussed, and finally some suggestions for future therapeutic developments will be presented.
尽管在过去几十年的临床前研究中付出了巨大努力，但将治疗性血管生成应用于在缺血性疾病患者中生长稳定且功能正常的血管的临床转化仍然具有挑战性。在这篇小型综述中，我们简要介绍了目前用于改善促血管生成疗法的主要方法。将讨论治疗性心脏血管生成和动脉生成研究中的具体例子，最后提出一些关于未来治疗发展的建议。
