巴西栗提取物及馏分的杀锥虫活性。

Trypanocidal activity of extracts and fractions of Bertholletia excelsa.

作者信息

Campos Francinete R, Januário Ana H, Rosas Lisandra V, Nascimento Samara K R, Pereira Paulo S, França Suzelei C, Cordeiro Milade S C, Toldo Miriam P A, Albuquerque Sérgio

机构信息

Departamento de Química, Universidade do Amazonas UA, Av. Gal. Otávio Rodrigo Jordão Ramos, 3000 69077-000 Manaus AM, Brazil.

出版信息

Fitoterapia. 2005 Jan;76(1):26-9. doi: 10.1016/j.fitote.2004.09.008.

DOI:10.1016/j.fitote.2004.09.008

PMID:15664458

Abstract

Crude extracts and fractions of Bertholletia excelsa stem barks were tested for trypanocidal activity. Acetone and methanol extracts showed significant in vitro trypanocidal activity against trypomastigote form of Trypanosoma cruzi since in the concentration of 500 microg/ml, the parasites were reduced in 100% and 90.3% respectively, whereas the triterpene betulinic acid pure isolated from hexane extract presented 75.4%.

摘要

对巴西栗茎皮的粗提物和馏分进行了杀锥虫活性测试。丙酮提取物和甲醇提取物对克氏锥虫的锥鞭毛体形式显示出显著的体外杀锥虫活性，因为在浓度为500微克/毫升时，寄生虫分别减少了100%和90.3%，而从己烷提取物中纯分离出的三萜桦木酸的杀锥虫活性为75.4%。