Takeara R, Albuquerque S, Lopes N P, Lopes J L C
Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Ribeirão Preto, SP, Brazil.
Phytomedicine. 2003;10(6-7):490-3. doi: 10.1078/094471103322331430.
In the continuing search for new compounds with trypanocidal activity for use in blood banks to prevent the transmission of Chagas' disease, a trypanocidal extract of Lychnophora staavioides Mart. (Vernonieae, Asteraceae) was fractionated using several chromatographic techniques and afforded the following flavonoids: tectochrysin, pinostrobin, pinobanksin, pinobanksin 3-acetate, pinocembrin, chrysin, galangin 3-methyl ether, quercetin 3-methyl ether, chrysoeriol and vicenin-2. The most active compound was quercetin 3-methyl ether, which showed no blood lysis activity and which represents a promising compound for use against T. cruzi in blood banks.
为了持续寻找可用于血库以预防恰加斯病传播的具有杀锥虫活性的新化合物，对菊科斑鸠菊族植物Lychnophora staavioides Mart.的一种杀锥虫提取物采用多种色谱技术进行分离，得到了以下黄酮类化合物：柚皮素、豆甾醇、刺槐素、刺槐素3 - 乙酸酯、松属素、白杨素、高良姜素3 - 甲醚、槲皮素3 - 甲醚、 Chrysoeriol和异荭草苷-2。活性最强的化合物是槲皮素3 - 甲醚，它没有血液溶解活性，是血库中用于对抗克氏锥虫的一种有前景的化合物。
