Roghani Mehrdad, Baluchnejadmojarad Tourandokht, Vaez-Mahdavi Mohammad Reza, Roghani-Dehkordi Farshad
Department of Physiology, School of Medicine, Shahed University, Dehkadeh Street, Keshavarz Blvd., P.O. Box: 14155-7435, Tehran, Iran.
Vascul Pharmacol. 2004 Aug;42(1):31-5. doi: 10.1016/j.vph.2004.12.001.
In this study, the mechanisms involved in vasorelaxant effect of the flavonoid quercetin was investigated in isolated aortic rings from streptozotocin (STZ)-diabetic rats. After 4 weeks, addition of quercetin (0.1 microM-1 mM) caused a significant dose-dependent relaxation of noradrenaline (NA)- and KCl-preconstricted rings in both control and diabetic groups with a significant inter-group difference of P<0.01. Furthermore, both nitro-L-arginine-methyl ester (L-NAME, 100 microM) and indomethacin (10 microM) markedly attenuated the vasorelaxant responses following quercetin application. Meanwhile, endothelium removal significantly attenuated the quercetin-induced vasorelaxation. It is concluded that the quercetin can relax the preconstricted rings of aorta in subchronic STZ-diabetic rats through nitric oxide- and -prostaglandin-mediated pathways, which themselves could be considered as endothelium-dependent.
在本研究中，对黄酮类化合物槲皮素在链脲佐菌素（STZ）诱导的糖尿病大鼠离体主动脉环中的血管舒张作用机制进行了研究。4周后，在对照组和糖尿病组中，添加槲皮素（0.1微摩尔/升至1毫摩尔/升）均能引起去甲肾上腺素（NA）和氯化钾预收缩环显著的剂量依赖性舒张，组间差异显著（P<0.01）。此外，硝基-L-精氨酸甲酯（L-NAME，100微摩尔/升）和吲哚美辛（10微摩尔/升）均能显著减弱槲皮素作用后的血管舒张反应。同时，去除内皮显著减弱了槲皮素诱导的血管舒张。结论是，槲皮素可通过一氧化氮和前列腺素介导的途径使亚慢性STZ糖尿病大鼠的主动脉预收缩环舒张，这些途径本身可被认为是内皮依赖性的。
