多瑞马草水醇提取物对链脲佐菌素-烟酰胺诱导的雄性大鼠2型糖尿病的抗糖尿病和降血脂作用
Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats.
作者信息
Ahangarpour Akram, Zamaneh Hossein Teymuri, Jabari Ayob, Nia Hamid Malekshahi, Heidari Hamid
机构信息
Health Research institute, Diabetes Research Center, Dept of Physiology, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Iran J Basic Med Sci. 2014 Oct;17(10):808-14.
OBJECTIVES
The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats.
MATERIALS AND METHODS
nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D. aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) for 4 weeks. Ultimately, blood of animals has taken and glucose, insulin, lipid profiles, SGPT, alkaline phosphatase, SGOT, leptin levels were assayed.
RESULTS
D. aucheri has highly significant blood glucose lowering effect. Administration of the extract to diabetic rats resulted in a remarkable change in serum lipid profiles, insulin and leptin levels relative to diabetic group. Also the extract reversed back the serum levels of SGPT, alkaline phosphatase and SGOT to near normal in treated diabetic rats.
CONCLUSION
D. aucheri could be useful in treatment of diabetes. Moderate dose of D. aucheri (200 mg/kg) was more effective than the others.
目的
本研究调查了多瑞玛草（Dorema aucheri）叶水醇提取物对烟酰胺-链脲佐菌素诱导的2型糖尿病大鼠的抗糖尿病和降血脂特性。
材料与方法
给烟酰胺/链脲佐菌素诱导的糖尿病大鼠口服补充三种不同剂量的多瑞玛草（100、200和400毫克/千克体重）或格列本脲（0.25毫克/千克），持续4周。最终，采集动物血液并检测血糖、胰岛素、血脂谱、谷丙转氨酶、碱性磷酸酶、谷草转氨酶、瘦素水平。
结果
多瑞玛草具有高度显著的降血糖作用。与糖尿病组相比，给糖尿病大鼠服用该提取物后，血清脂质谱、胰岛素和瘦素水平发生了显著变化。此外，该提取物使治疗的糖尿病大鼠血清谷丙转氨酶、碱性磷酸酶和谷草转氨酶水平恢复到接近正常。
结论
多瑞玛草可能对糖尿病治疗有用。中等剂量的多瑞玛草（200毫克/千克）比其他剂量更有效。
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