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不同的巴西利什曼原虫分离株诱导趋化因子表达模式的不同变化速度。

Distinct Leishmania braziliensis isolates induce different paces of chemokine expression patterns.

作者信息

Teixeira Maria Jania, Fernandes Juliana Dumet, Teixeira Clarissa Romero, Andrade Bruno Bezerril, Pompeu Margarida Lima, Santana da Silva João, Brodskyn Cláudia Ida, Barral-Netto Manoel, Barral Aldina

机构信息

Centro de Pesquisas Gonçalo Moniz-Fiocruz-BA, 121 Rua Waldemar Falcão, Salvador, Bahia, Brazil 40295-001.

出版信息

Infect Immun. 2005 Feb;73(2):1191-5. doi: 10.1128/IAI.73.2.1191-1195.2005.

DOI:10.1128/IAI.73.2.1191-1195.2005
PMID:15664963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC546968/
Abstract

Inflammatory events during Leishmania braziliensis infection in mice were investigated. Large lesions were directly correlated with the inflammatory reaction but not with parasite burden. Different L. braziliensis strains induce different paces of chemokine expression patterns, leading to diverse cell recruitment and differential inflammatory responses.

摘要

对巴西利什曼原虫感染小鼠期间的炎症事件进行了研究。大的病变与炎症反应直接相关，但与寄生虫负荷无关。不同的巴西利什曼原虫菌株诱导趋化因子表达模式的不同速度，导致不同的细胞募集和不同的炎症反应。

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本文引用的文献

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Leishmania braziliensis isolates differing at the genome level display distinctive features in BALB/c mice.在基因组水平上存在差异的巴西利什曼原虫分离株在BALB/c小鼠中表现出独特的特征。
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[American cutaneous leishmaniasis].[美洲皮肤利什曼病]
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Adenoviral-mediated gene transfer of lymphotactin to the lungs of mice and rats results in infiltration and direct accumulation of CD4+, CD8+, and NK cells.腺病毒介导的淋巴细胞趋化因子基因转移至小鼠和大鼠肺部，会导致CD4 +、CD8 +和NK细胞浸润并直接聚集。
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MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines.巨噬细胞炎性蛋白-1α、巨噬细胞炎性蛋白-1β、调节激活正常T细胞表达和分泌因子以及活化调节趋化因子/淋巴细胞趋化因子与γ干扰素共同作为1型细胞因子发挥作用。
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Patterns of chemokine expression in models of Schistosoma mansoni inflammation and infection reveal relationships between type 1 and type 2 responses and chemokines in vivo.曼氏血吸虫炎症和感染模型中趋化因子的表达模式揭示了1型和2型反应与体内趋化因子之间的关系。
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Regulatory effects of macrophage inflammatory protein 1alpha/CCL3 on the development of immunity to Cryptococcus neoformans depend on expression of early inflammatory cytokines.巨噬细胞炎性蛋白1α/CCL3对新型隐球菌免疫发育的调节作用取决于早期炎性细胞因子的表达。
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