Dressler D
Klinik für Neurologie, Universität Rostock.
Nervenarzt. 2005 Jun;76(6):763-6. doi: 10.1007/s00115-004-1857-6.
Fresh fish products are exquisitely prone to be the source for food botulism because of primary contamination with Clostridium botulinum spores, lack of heat inactivation of C. botulinum spores, frequently used air-tight packaging, lack of preservatives, lack of heat inactivation of already produced botulinum toxin and because of substantial low temperature resistance of C. botulinum type E typically found in fish botulism. We can reporting a 25-year-old patient with food botulism presenting with an anticholinergic syndrome with mydriasis, accommodation difficulties, dryness of mouth, reduced sweating, constipation and reduced heart rate variance and only discrete involvement of striate muscles with ptosis, diplopia and generalised fatigue, all of which developed 12 h after the consumption of airtight sealed smoked salmon. The salmon was consumed 3 days after the 'use by' date had expired.
新鲜鱼制品极易成为肉毒中毒的食物来源,原因在于其最初被肉毒梭菌孢子污染、肉毒梭菌孢子缺乏热灭活、常用气密包装、缺乏防腐剂、已产生的肉毒毒素缺乏热灭活,以及鱼源性肉毒中毒中常见的E型肉毒梭菌具有显著的低温耐受性。我们报告一例25岁肉毒中毒患者,表现为抗胆碱能综合征,有瞳孔散大、调节困难、口干、出汗减少、便秘和心率变异性降低,仅有眼外肌轻度受累,出现上睑下垂、复视和全身乏力,所有这些症状在食用气密包装的烟熏三文鱼12小时后出现。该三文鱼是在“保质期”过期3天后食用的。