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重症监护病房中80岁及以上患者的治疗强度与预后:一项多中心匹配队列研究。

Treatment intensity and outcome of patients aged 80 and older in intensive care units: a multicenter matched-cohort study.

作者信息

Boumendil Ariane, Aegerter Philippe, Guidet Bertrand

机构信息

INSERM U444, Faculté de médecine Saint-Antoine, Paris, France.

出版信息

J Am Geriatr Soc. 2005 Jan;53(1):88-93. doi: 10.1111/j.1532-5415.2005.53016.x.

Abstract

OBJECTIVES

To determine whether patients aged 80 and older have similar treatment intensity to that of younger patients in the intensive care unit (ICU).

DESIGN

Multicenter, matched-cohort study.

SETTING

Data were extracted from a multicenter database with 36 ICUs in the Paris area (France) during a 4-year period (1997-2000).

PARTICIPANTS

Three thousand one hundred seventy-five patients aged 80 and older (oldest-old) were retrospectively matched to 3,175 patients aged 65 to 79 (young-old).

MEASUREMENTS

The matching criteria were severity status on admission (+/-2) (assessed using a corrected Simplified Acute Physiology Score II leaving out age points), Charlson Comorbidity Index, type of admission (surgical vs medical), sex, admission to same ICU, and year of ICU admission. The underlying condition was classified using the McCabe classification. The functional status was assessed using the Knaus classification. The ICU workload was assessed using the OMEGA scoring system.

RESULTS

Total and daily workload were lower in the oldest-old than in matched young-old patients. Estimated mean direct medical cost per stay was approximately 1,280 dollars lower for oldest-old patients. Older patients received less mechanical ventilation (adjusted odds ratio (AOR)=0.69, 95% confidence interval (CI)=0.61-0.78), less tracheostomy (AOR=0.37, 95% CI=0.28-0.50), and less renal support (AOR=0.52, 95% CI=0.41-0.66) than matched young-old patients. Oldest-old patients had a shorter length of ICU stay than matched young-old patients and the same length of post-ICU stay.

CONCLUSION

Oldest-old patients receive less treatment in the ICU than young-old patients even after adjustment for severity of illness.

摘要

目的

确定80岁及以上患者在重症监护病房(ICU)的治疗强度是否与年轻患者相似。

设计

多中心、匹配队列研究。

地点

数据来自法国巴黎地区36个ICU的多中心数据库,时间跨度为4年(1997 - 2000年)。

参与者

3175名80岁及以上的患者(高龄老人)与3175名65至79岁的患者(老年)进行回顾性匹配。

测量指标

匹配标准包括入院时的严重程度状态(±2)(使用校正的简化急性生理学评分II评估,不包括年龄得分)、查尔森合并症指数、入院类型(手术 vs 内科)、性别、入住同一ICU以及ICU入院年份。基础疾病使用麦凯布分类法进行分类。功能状态使用克瑙斯分类法进行评估。ICU工作量使用OMEGA评分系统进行评估。

结果

高龄老人的总工作量和每日工作量均低于匹配的老年患者。高龄老人每次住院的估计平均直接医疗费用比老年患者低约1280美元。与匹配的老年患者相比,老年患者接受机械通气的比例更低(调整优势比(AOR)=0.69,95%置信区间(CI)=0.61 - 0.78),气管切开术的比例更低(AOR = 0.37,95% CI = 0.28 - 0.50),肾脏支持的比例更低(AOR = 0.52,95% CI = 0.41 - 0.66)。高龄老人在ICU的住院时间比匹配的老年患者短,且ICU后住院时间相同。

结论

即使在对疾病严重程度进行调整后,高龄老人在ICU接受的治疗仍比老年患者少。

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