医疗及职业环境中的颅内脑膜瘤与电离辐射

Intracranial meningioma and ionizing radiation in medical and occupational settings.

作者信息

Phillips L E, Frankenfeld C L, Drangsholt M, Koepsell T D, van Belle G, Longstreth W T

机构信息

Neuroepidemiology Group, Department of Epidemiology,School of Public Health and Community Medicine, University of Washington, Seattle, USA.

出版信息

Neurology. 2005 Jan 25;64(2):350-2. doi: 10.1212/01.WNL.0000149766.65843.19.

DOI:10.1212/01.WNL.0000149766.65843.19

PMID:15668439

Abstract

In a population-based case-control study of 200 cases and 400 controls in western Washington State, the authors assessed associations between meningioma and ionizing radiation in medical and occupational settings. No significant associations were observed for diagnostic studies or occupational settings, but associations were observed for radiation therapy to head or neck (odds ratio 3.7, 95% CI 1.5 to 9.5), especially for neoplastic conditions. Only four patients (2%) had meningiomas that followed high-dose cranial radiation.

摘要

在华盛顿州西部开展的一项基于人群的病例对照研究中，研究对象包括200例病例和400例对照，作者评估了医疗和职业环境中脑膜瘤与电离辐射之间的关联。对于诊断性检查或职业环境，未观察到显著关联，但对头颈部放射治疗观察到了关联（比值比3.7，95%置信区间1.5至9.5），尤其是对于肿瘤性疾病。只有4例患者（2%）的脑膜瘤发生在高剂量颅脑放疗之后。