Kelly K-L J, Craighead P S
Department of Radiation Oncology, Tom Baker Cancer Centre, 1331-29 Street NW, Calgary, Alberta T2N 4N2, Canada.
Int J Gynecol Cancer. 2005 Jan-Feb;15(1):132-9. doi: 10.1111/j.1048-891x.2005.15014.x.
The purpose of this study was to evaluate patients with uterine sarcoma from Southern Alberta to assess patterns of care and outcomes associated with treatment by a multidisciplinary team. Using the Alberta Cancer Registry database, charts of all uterine sarcoma patients treated between 1988 and 1997 in Southern Alberta were extracted. The majority of patients underwent definitive surgery. Adjuvant treatments were performed in selected patients at the discretion of the multidisciplinary tumor board. Demographics, management, and outcomes were collected into an electronic database. Eighty-seven patients were treated for uterine sarcoma at the Tom Baker Cancer Centre from 1988 to 1997. The 5-year overall survival rate was 48% and the 10-year overall survival rate was 21%. Univariate analysis demonstrated that stage, histologic subtype, and treatment with radiation therapy had a significant effect on local control and that stage and histologic subtype had a significant effect on survival. Stage was significant in the multivariate analysis for both local control (P = 0.008) and overall survival (P = 0.0001). Based on the findings in this series, stage remains a significant prognostic factor for patients with uterine sarcoma. Multidisciplinary care in the local setting reduced the use of adjuvant therapy without impacting adversely on survival or local control.
本研究的目的是评估来自阿尔伯塔省南部的子宫肉瘤患者，以评估多学科团队治疗的护理模式及相关预后。利用阿尔伯塔癌症登记数据库，提取了1988年至1997年间在阿尔伯塔省南部接受治疗的所有子宫肉瘤患者的病历。大多数患者接受了根治性手术。多学科肿瘤委员会酌情为部分患者进行了辅助治疗。将人口统计学、治疗管理及预后情况录入电子数据库。1988年至1997年期间，有87例子宫肉瘤患者在汤姆·贝克癌症中心接受治疗。5年总生存率为48%，10年总生存率为21%。单因素分析表明，分期、组织学亚型及放疗对局部控制有显著影响，分期和组织学亚型对生存率有显著影响。在多因素分析中，分期对局部控制（P = 0.008）和总生存率（P = 0.0001）均有显著意义。基于本系列研究结果，分期仍是子宫肉瘤患者的重要预后因素。在当地进行多学科护理减少了辅助治疗的使用，且未对生存率或局部控制产生不利影响。
