O'Donnell Shannon, Noseworthy Michael D, Levine Brian, Dennis Maureen
Brain and Behaviour Program, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
Neuroimage. 2005 Feb 15;24(4):948-54. doi: 10.1016/j.neuroimage.2004.10.014. Epub 2004 Dec 15.
The development of the frontopolar cortex (FPC) through late childhood and adolescence was investigated using measures of cortical thickness. T(1)-weighted structural MRIs from 35 typically developing participants aged 8-20 years were used to construct 3D models of the brain, from which cortical thickness was measured. There was a significant inverse association between age and cortical thickness, such that cortical thickness decreased as age increased between 8 and 20 years. There was no effect of laterality or gender on cortical thickness.
利用皮质厚度测量方法，对儿童晚期和青少年期前额极皮质（FPC）的发育进行了研究。使用了35名年龄在8至20岁之间发育正常参与者的T(1)加权结构磁共振成像（MRI）来构建大脑的三维模型，并从中测量皮质厚度。年龄与皮质厚度之间存在显著的负相关关系，即在8至20岁之间，随着年龄的增长，皮质厚度会下降。皮质厚度不受脑区偏侧性或性别的影响。
