Moss Timothy J M, Doherty Dorota A, Nitsos Ilias, Sloboda Deborah M, Harding Richard, Newnham John P
School of Women's and Infants' Health, The University of Western Australia, Crawley, Australia.
Am J Obstet Gynecol. 2005 Jan;192(1):146-52. doi: 10.1016/j.ajog.2004.06.065.
To determine effects of maternal or fetal injections of betamethasone on postnatal growth and arterial pressure.
We measured body weight, arterial pressure, and heart rate serially in sheep born after single or repeated maternal or fetal betamethasone injections. At approximately 3.5 years, organ weights were measured.
Repeated maternal betamethasone injections caused intrauterine growth restriction, and low body weight and blood pressure at 3 months. From 6 months to 3 years, body weight, blood pressure, and heart rate were not affected by treatment. At approximately 3.5 years, brain weight was reduced after single or repeated maternal betamethasone by 13% and 18%, respectively (P = .001). Fetal betamethasone reduced brain weight by 7% to 8% (P = .018). Weights of other organs were not affected by treatment. Brain weight was unrelated to body weight at approximately 3.5 years (P = .649) but was related to birth weight (P = .029).
Prenatal betamethasone does not have long-term effects on blood pressure but causes a persistent deficit in brain weight.
确定母体或胎儿注射倍他米松对产后生长和动脉血压的影响。
我们连续测量了单次或重复母体或胎儿注射倍他米松后出生的绵羊的体重、动脉血压和心率。在大约3.5岁时，测量器官重量。
重复母体注射倍他米松导致宫内生长受限，3个月时体重和血压较低。从6个月到3岁，体重、血压和心率不受治疗影响。在大约3.5岁时，单次或重复母体注射倍他米松后，脑重量分别减少了13%和18%（P = .001）。胎儿注射倍他米松使脑重量减少了7%至8%（P = .018）。其他器官的重量不受治疗影响。在大约3.5岁时，脑重量与体重无关（P = .649），但与出生体重有关（P = .029）。
产前倍他米松对血压没有长期影响，但会导致脑重量持续不足。
