Page Philip C Bulman, Buckley Benjamin R, Heaney Harry, Blacker A John
Department of Chemistry, Loughborough University, Loughborough, Leicestershire LE11 3TU, England.
Org Lett. 2005 Feb 3;7(3):375-7. doi: 10.1021/ol047836h.
[reaction: see text] A range of cis-substituted olefins has been epoxidized with a new dihydroisoquinolinium salt catalyst, using tetraphenylphosphonium monoperoxysulfate as the stoichiometric oxidant, giving ee's of up to 97%. The reaction has been used as the key step in an enantioselective synthesis of the antihypertensive agent levcromakalim.
[反应：见正文] 一系列顺式取代的烯烃已用一种新型二氢异喹啉鎓盐催化剂进行环氧化反应，以四苯基鏻单过氧硫酸盐作为化学计量氧化剂，对映体过量值高达97%。该反应已被用作抗高血压药物左卡尼汀对映选择性合成中的关键步骤。
