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Clonal spread of a Clostridium difficile strain with a complete set of toxin A, toxin B, and binary toxin genes among Polish patients with Clostridium difficile-associated diarrhea.一株携带完整毒素A、毒素B和二元毒素基因的艰难梭菌在波兰艰难梭菌相关性腹泻患者中的克隆传播。
J Clin Microbiol. 2005 Jan;43(1):472-5. doi: 10.1128/JCM.43.1.472-475.2005.
2
Clonal dissemination of a toxin-A-negative/toxin-B-positive Clostridium difficile strain from patients with antibiotic-associated diarrhea in Poland.波兰抗生素相关性腹泻患者中一株毒素A阴性/毒素B阳性艰难梭菌菌株的克隆传播。
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Correlation of disease severity with fecal toxin levels in patients with Clostridium difficile-associated diarrhea and distribution of PCR ribotypes and toxin yields in vitro of corresponding isolates.艰难梭菌相关性腹泻患者疾病严重程度与粪便毒素水平的相关性以及相应分离株的PCR核糖型分布和体外毒素产量
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Pseudomembranous colitis caused by toxin A-negative/toxin B-positive variant strain of Clostridium difficile.由艰难梭菌毒素A阴性/毒素B阳性变异菌株引起的伪膜性结肠炎。
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Emergence of a Novel Binary Toxin-Positive Strain of Clostridium difficile Associated With Severe Diarrhea That Was Not Ribotype 027 and 078 in China.中国出现一种新型二元毒素阳性艰难梭菌菌株，与严重腹泻相关，该菌株不属于核糖体分型027和078。
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3
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Rapid detection of the Clostridium difficile ribotype 027 tcdC gene frame shift mutation at position 117 by real-time PCR and melt curve analysis.通过实时荧光定量聚合酶链反应和熔解曲线分析快速检测艰难梭菌核糖体分型027 tcdC基因第117位的移码突变。
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本文引用的文献

1
Binary toxin producing Clostridium difficile strains.产生二元毒素的艰难梭菌菌株。
Anaerobe. 2003 Dec;9(6):289-94. doi: 10.1016/j.anaerobe.2003.09.002.
2
Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile.艰难梭菌二元毒素（肌动蛋白特异性 ADP 核糖基转移酶）的流行情况及特性
J Clin Microbiol. 2004 May;42(5):1933-9. doi: 10.1128/JCM.42.5.1933-1939.2004.
3
Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping.通过扩增片段长度多态性和PCR核糖体分型对来自不同国家暴发疫情的产毒素A阴性、产毒素B阳性艰难梭菌分离株进行特征分析。
J Clin Microbiol. 2004 Mar;42(3):1035-41. doi: 10.1128/JCM.42.3.1035-1041.2004.
4
Frequency of binary toxin genes among Clostridium difficile strains that do not produce large clostridial toxins.不产生大梭菌毒素的艰难梭菌菌株中二元毒素基因的频率。
J Clin Microbiol. 2003 Nov;41(11):5227-32. doi: 10.1128/JCM.41.11.5227-5232.2003.
5
Recent emergence of an epidemic clindamycin-resistant clone of Clostridium difficile among Polish patients with C. difficile-associated diarrhea.近期，在波兰患有艰难梭菌相关性腹泻的患者中出现了一种对克林霉素耐药的流行艰难梭菌克隆。
J Clin Microbiol. 2003 Sep;41(9):4184-7. doi: 10.1128/JCM.41.9.4184-4187.2003.
6
International typing study of toxin A-negative, toxin B-positive Clostridium difficile variants.毒素A阴性、毒素B阳性艰难梭菌变体的国际分型研究
J Clin Microbiol. 2003 Apr;41(4):1543-7. doi: 10.1128/JCM.41.4.1543-1547.2003.
7
Clostridium difficile testing: after 20 years, still challenging.艰难梭菌检测：历经20年，仍具挑战性。
J Clin Microbiol. 2003 Feb;41(2):531-4. doi: 10.1128/JCM.41.2.531-534.2003.
8
Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates.艰难梭菌临床分离株中毒素产生假定负调控因子（TcdC）的致病性位点及多态性的分子分析
J Clin Microbiol. 2002 Sep;40(9):3470-5. doi: 10.1128/JCM.40.9.3470-3475.2002.
9
ADP-ribosylating binary toxin genes of Clostridium difficile strain CCUG 20309.艰难梭菌菌株CCUG 20309的ADP核糖基化二元毒素基因
DNA Seq. 2001;12(2):115-20. doi: 10.3109/10425170109047564.
10
Clonal dissemination of a toxin-A-negative/toxin-B-positive Clostridium difficile strain from patients with antibiotic-associated diarrhea in Poland.波兰抗生素相关性腹泻患者中一株毒素A阴性/毒素B阳性艰难梭菌菌株的克隆传播。
Clin Microbiol Infect. 2001 Aug;7(8):442-6. doi: 10.1046/j.1198-743x.2001.00312.x.

一株携带完整毒素A、毒素B和二元毒素基因的艰难梭菌在波兰艰难梭菌相关性腹泻患者中的克隆传播。

Clonal spread of a Clostridium difficile strain with a complete set of toxin A, toxin B, and binary toxin genes among Polish patients with Clostridium difficile-associated diarrhea.

作者信息

Pituch Hanna, Kreft Deborah, Obuch-Woszczatynski Piotr, Wultańska Dorota, Meisel-Mikołajczyk Felicja, Łuczak Mirosław, van Belkum Alex

机构信息

Department of Medical Microbiology, The Medical University of Warsaw, 5 Chalubinski Street, 02-004 Warsaw, Poland.

出版信息

J Clin Microbiol. 2005 Jan;43(1):472-5. doi: 10.1128/JCM.43.1.472-475.2005.

DOI:10.1128/JCM.43.1.472-475.2005
PMID:15635019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC540144/
Abstract

Clinically relevant Clostridium difficile strains usually produce toxins A and B. Some C. difficile strains can produce an additional binary toxin. We report clonality among five strains carrying all toxin genes from Polish patients with C. difficile-associated diarrhea. In another strain, possible recombination between binary toxin genes is documented.

摘要

具有临床相关性的艰难梭菌菌株通常会产生毒素A和毒素B。一些艰难梭菌菌株还可产生一种额外的二元毒素。我们报告了来自波兰艰难梭菌相关性腹泻患者的五株携带所有毒素基因的菌株之间的克隆性。在另一株菌株中，记录到二元毒素基因之间可能发生了重组。