Roberts C J, Sekowski M, Davies M C, Jackson D E, Price M R, Tendler S J
VG STM Laboratory for Biological Applications, Department of Pharmaceutical Sciences, Nottingham, U.K.
Biochem J. 1992 Apr 1;283 ( Pt 1)(Pt 1):181-5. doi: 10.1042/bj2830181.
Human polymorphic epithelial mucin is a high-molecular-mass glycoprotein that associates to provide protection to the epithelial-cell surface and may afford the malignant cell a selective advantage for growth. The scanning-tunnelling-microscopy micrographs obtained in the present study identify the purified human ovarian-carcinoma polymorphic epithelial mucin glycoproteins as rod-shaped molecules of mixed length. The dimensions of the individual molecules range from 25 to 45 nm in length and are 3-4 nm in width. The images further suggest that lateral association of the rods occurs.
人多形上皮粘蛋白是一种高分子量糖蛋白，其相互结合可为上皮细胞表面提供保护，并且可能赋予恶性细胞生长的选择性优势。本研究获得的扫描隧道显微镜显微照片显示，纯化的人卵巢癌多形上皮粘蛋白糖蛋白为长度各异的杆状分子。单个分子的长度范围为25至45纳米，宽度为3至4纳米。这些图像进一步表明这些杆状分子会发生侧向结合。
