在氟康唑临床应用之前分离得到的光滑念珠菌菌株迅速获得稳定的唑类耐药性。
Rapid acquisition of stable azole resistance by Candida glabrata isolates obtained before the clinical introduction of fluconazole.
作者信息
Borst Annemarie, Raimer Maria T, Warnock David W, Morrison Christine J, Arthington-Skaggs Beth A
机构信息
Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., N.E., Mailstop G-11, Atlanta, GA 30333, USA.
出版信息
Antimicrob Agents Chemother. 2005 Feb;49(2):783-7. doi: 10.1128/AAC.49.2.783-787.2005.
Abstract
Five azole-susceptible Candida glabrata isolates obtained before 1975 became resistant to fluconazole, itraconazole, and voriconazole within 4 days of in vitro fluconazole exposure. This cross-resistance was stable for at least 4 months after removal of fluconazole and was associated with increased CgCDR1 and CgCDR2 expression.
摘要
1975年之前获得的5株对唑类敏感的光滑念珠菌分离株，在体外暴露于氟康唑4天内便对氟康唑、伊曲康唑和伏立康唑产生了耐药性。这种交叉耐药性在去除氟康唑后至少4个月内保持稳定，并且与CgCDR1和CgCDR2表达增加有关。
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