Plaghki Léon, Mouraux André
Unité de Réadaptation et Médecine Physique (READ), Université Catholique de Louvain, B-1200 Brussels, Belgium.
Curr Opin Investig Drugs. 2005 Jan;6(1):58-64.
Laser heat stimulators selectively activate Adelta and C-nociceptors in the superficial layers of the skin. Their high power output produces steep heating ramps, which improve synchronization of afferent volleys and therefore allow the recording of time-locked events, such as laser-evoked brain potentials. Study of the electrical brain activity evoked by Adelta- and C-nociceptor afferent volleys revealed the existence of an extensive, sequentially activated, cortical network. These electrophysiological responses are modulated by stimulus-driven and, even more extensively, top-down processes. The specificity and validity of these components for pain research are currently under intense scrutiny.
激光热刺激器可选择性激活皮肤表层的 Aδ 和 C 伤害感受器。其高功率输出会产生陡峭的加热斜坡，这改善了传入神经冲动的同步性，因此能够记录与时间锁定的事件，如激光诱发的脑电位。对由 Aδ 和 C 伤害感受器传入神经冲动诱发的脑电活动的研究揭示了一个广泛的、顺序激活的皮质网络的存在。这些电生理反应受刺激驱动调节，甚至更广泛地受自上而下的过程调节。目前，这些成分在疼痛研究中的特异性和有效性正受到严格审查。
